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1H-Benzimidazole-2-propanamide, β-amino-6-(1,1-dimethylethyl)-α-methyl-, (αR,βS)-

PF-06305591

CAS: 1449473-97-5

Molecular Formula: C15H22N4O

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1H-Benzimidazole-2-propanamide, β-amino-6-(1,1-dimethylethyl)-α-methyl-, (αR,βS)- - Names and Identifiers

Name PF-06305591
Synonyms PF-06305591
(2R,3S)-3-amino-3-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)-2-methylpropanamide
1H-Benzimidazole-2-propanamide, β-amino-6-(1,1-dimethylethyl)-α-methyl-, (αR,βS)-
CAS 1449473-97-5

1H-Benzimidazole-2-propanamide, β-amino-6-(1,1-dimethylethyl)-α-methyl-, (αR,βS)- - Physico-chemical Properties

Molecular FormulaC15H22N4O
Molar Mass274.36
Density1.176±0.06 g/cm3(Predicted)
Boling Point537.8±50.0 °C(Predicted)
pKa11.89±0.10(Predicted)
In vitro study PF-06305591 (compound 9) has a highly attractive profile with respect to NaV selectivity, hERG activity, passive permeability and in vitro metabolic stability.
In vivo study PF-06305591 (compound 9) has good rat bioavailability. PF-06305591 offers the possibility of investigating higher IC 50 multiples of Nav1.8 blockade in the clinic, and therefore a more thorough evaluation of the role of NaV1.8 in the treatment of pain.
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1H-Benzimidazole-2-propanamide, β-amino-6-(1,1-dimethylethyl)-α-methyl-, (αR,βS)-
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